Physical training in the treatment of depressive disorders
by
Broocks A, Ahrendt U, Sommer M.
Carl-Friedrich-Flemming-Klinik,
HELIOS-Kliniken Schwerin,
Wismarsche Strasse 393-397, 19055 Schwerin.
abroocks@schwerin.helios-kliniken.de
Psychiatr Prax. 2007 Sep;34 Suppl 3:S300-4.


ABSTRACT

Therapeutic exercise programs have become an obligatory component in the modern treatment of many internal and orthopaedic conditions. In the field of psychiatry, the interaction of physical fitness and mental well-being has been increasingly recognized. In the meanwhile, solid evidence has emerged that regular exercise is associated with therapeutic effects in psychiatric patients suffering from depressive and possibly other psychiatric disorders. The present article reviews the relevant literature and summarizes neurobiological effects of exercise which might play a role in the effectiveness of therapeutic exercise. For instance, there is experimental evidence, that regular exercise induces a downregulation of central 5-HT(2C) receptors which play an important role in the pathogenesis of anxiety and depression. The production of brain-derived neurotrophic factor (BDNF)is stimulated in several brain regions. In conclusion, practical aspects and motivational factors have to be regarded in order to successfully establish exercise programs in the treatment of psychiatric disorders.
BDNF
SAMe
Folate
Inositol
Serotonin
Chromium
Low-fat blues
Antidepressants
Vitamins and mood
Exercise and health
Nutritional psychiatry
Docosahexaenoic acid
Exercise and depression
Catecholamine depletion
Mood, food and cognition
Bad moods and sick hearts
Exercise and new brain cells
Exercise as an antidepressant
Phenylethylamine and exercise
NO, BDNF, exercise and antidepressants
Sensory pleasure optimizes muscular work
Runners' high: exercise and endogenous opioid release
The exercise-regulated gene VGF: antidepressant action
Major depression: exercise as an augmentation strategy
Vigorous exercise increases BDNF and receptors and prevents middle-age stem cell drop


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