Chronic epi-inositol has an anxiolytic-like
effect in the plus-maze model in rats

by
Einat H, Elkabaz-Shwortz Z, Cohen H,
Kofman O, Belmaker RH.
Faculty of Health Sciences,
Ben Gurion University of the Negev,
Beer Sheva, Israel.
Int J Neuropsychopharmcol. 1998 Jul;1(1):31-34


ABSTRACT

Behavioural effects of myo-inositol have been demonstrated in animal models of psychiatric disorders and in clinical trials in psychiatric patients. These effects of myo-inositol were thought to be consequences of its being a substrate for the enzyme phosphatidylinositol (PI) synthase. Recently, epi-inositol, an unnatural stereoisomer of myo-inositol that is not a substrate for PI synthase, was found to also have effects similar to those of myoinositol to reverse lithium-pilocarpine seizures. The present study measured the behaviour of rats in an elevated plus-maze model of anxiety after chronic treatment of 11 daily i.p. injections of epi-inositol, myo-inositol, or control solution. Epi-inositol reduced levels of anxiety-like behaviour in rats compared with controls, and its effect was stronger than that of myo-inositol. The increased relative effect of epi-inositol could be due to slower metabolism or to a different mechanism of action.


Lithium
Gabapentin
Lamotrigine
Bipolar disorders
Inositol depletion
Lithium prophylaxis
Myo-inositol/lithium
Inositol and bipolar disorder
Inositol as an antidepressant


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family