Emotional blunting associated with SSRI-induced
sexual dysfunction. Do SSRIs inhibit emotional responses?
Opbroek A, Delgado PL, Laukes C, McGahuey C,
Katsanis J, Moreno FA, Manber R.
Int J Neuropsychopharmacol 2002 Jun;5(2):147-51
ABSTRACTAnecdotal and published case reports suggest that some patients taking selective serotonin reuptake inhibitors (SSRI) experience diminution in emotional responsiveness. This study aims to define the individual components of emotion disturbed in these patients. Fifteen patients reporting SSRI-induced sexual dysfunction completed the Laukes Emotional Intensity Scale (LEIS), a questionnaire about various emotions. Compared to controls, patients reported significantly (p&0.05) less ability to cry, irritation, care about others' feelings, sadness, erotic dreaming, creativity, surprise, anger, expression of their feelings, worry over things or situations, sexual pleasure, and interest in sex. Total score on the LEIS did not correlate with total score on the Hamilton Depression Rating Scale. In our sample, 80% of patients with SSRI-induced sexual dysfunction also describe clinically significant blunting of several emotions. Emotional blunting may be an under-appreciated side-effect of SSRIs that may contribute to treatment non-compliance and/or reduced quality of life.TCAs
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Serotonin control genes
Pleasure, decision and desire
Where are we going with SSRIs?
Antidepressant drugs and emotion
Dapoxetine v paroxetine to treat PE
Premature ejaculation and serotonin
Drugs to treat premature ejaculation
Are SSRI antidepressants little better than placebos?
Selective serotonin reuptake inhibitors reduce emotional lability
and further reading
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family