Dopaminergic abnormalities in amygdaloid nuclei
in major depression: a postmortem study

by
Klimek V, Schenck J, Han H, Stockmeier C, Ordway G.
Department of Psychiatry and Human Behavior,
University of Mississippi Medical Center,
Jackson, Mississippi, USA
Biol Psychiatry 2002 Oct 1;52(7):740


ABSTRACT

A deficiency of mesolimbic dopamine (DA) is a leading candidate for the etiology of certain symptoms of depression (e.g., anhedonia and loss of motivation). Here we show amounts of dopaminergic proteins in the amygdala, a key brain structure involved in the integration of emotions and stress, in subjects with major depression and in psychiatrically normal control subjects.The specific binding of [(125)I]RTI 55 to the DA transporter, [(3)H]SCH 23390 to the D1 receptor and [(125)I]epidepride to D2/D3 receptors were measured in the right amygdaloid complex in postmortem brains from 11 subjects with major depression and 11 matched control subjects.The binding of [(125)I]RTI 55 to DA transporter was significantly lower in the basal and central amygdaloid nuclei, whereas the binding of [(125)I]epidepride to D2/D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. No difference in the binding of [(3)H]SCH 23390 to D1 receptors was observed.Given that DA depletion in rats can induce a reduction in the DA transporter and an upregulation of D2/D3 receptors, our data are consistent with the hypothesis that major depression is associated with a deficiency of mesolimbic DA.
Structure
Selegiline
Roxindole
Dopamine
Amineptine
Pramipexole
Bromocriptine
Methylphenidate
Tranylcypromine
Drugs and reward
Dopamine and sex
Dopamine and thought
The dopamine transporter
Dopamine knock-out mice
The pleasure and the pain
Dopamine deficiency and depression
Depression, dopamine and dextroamphetamine
Mesolimbic medium spiny neurons and pleasure
Regulation of synapses in the nucleus accumbens
The nucleus accumbens: opioids versus cannabinoids
Dopamine's role in reward: the case for incentive salience
Greater availability of dopamine transporters in depression


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family