Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation
Modi NB, Dresser MJ, Simon M, Lin D, Desai D, Gupta S.
ALZA Corporation, 1900 Charleston Road,
Building M11-4A, Mountain View, CA 94043, USA.
J Clin Pharmacol. 2006 Mar;46(3):301-9.


Dapoxetine is a serotonin transporter inhibitor currently in development for the treatment of premature ejaculation. This randomized, 2-sequence, 2-treatment crossover study assessed the single- and multiple-dose pharmacokinetics of dapoxetine following once-daily administration of dapoxetine 30 mg and 60 mg to healthy male volunteers. Dapoxetine was rapidly absorbed following oral administration, with peak plasma concentrations reached approximately 1 hour after dosing; plasma concentrations after single doses of dapoxetine decreased rapidly to approximately 5% of peak concentrations by 24 hours. Elimination was biphasic, with an initial half-life of approximately 1.4 hours and a terminal half-life of approximately 20 hours. Dapoxetine showed time-invariant pharmacokinetics and dose proportionality between doses, and its pharmacokinetics was unaffected by multiple dosing. The pharmacokinetics of dapoxetine metabolites, desmethyldapoxetine and dapoxetine-N-oxide, was similarly unaffected by multiple dosing. There were no serious adverse events; the most commonly reported adverse events were diarrhea, dizziness, and nausea.
Drugs and sex
Designer aphrodisiacs
Viagra: clinical efficacy
Antidepressants and sex
SSRIs and disinhibited libido?
SSRIs and sexual functioning
Lifelong premature ejaculation
Dapoxetine v paroxetine to treat PE
Premature ejaculation and serotonin
Drugs to treat premature ejaculation
Premature ejaculation: alternative therapies
Male sexual heath : disorders of orgasm and ejaculation

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