Genetic variants of dopamine
receptor D4 and psychopathology

by
Serretti A, Macciardi F, Catalano M, Bellodi L, Smeraldi E
Department of Psychiatry,
Istituto Scientifico H. San Raffaele,
University of Milano School of Medicine, Italy.
Schizophr Bull 1999; 25(3):609-18


ABSTRACT

There is much evidence to indicate that the dopamine receptor D4 (DRD4) gene is involved in psychiatric disorders. We investigated the correlation between DRD4 gene polymorphism and the psychopathology of major psychoses, independently of diagnoses. Some 461 inpatients affected by major psychoses were assessed by the Operational Criteria checklist for psychotic illness and typed for DRD4 variants. The four symptomatologic factors-mania, depression, delusion, and disorganization-were used as phenotype definitions. DRD4 Exon 3 long allele variants were associated with high delusional scores, with the most significant difference between alleles 2 and 7 (p = 0.004). DRD4 variants may, therefore, constitute a liability factor for development of delusional symptomatology in patients with major psychoses.
D4
D3
D2
D1+D2
Reward
Deliriants
Neuroleptics
Dopamine and sex
D4-knockout mice
D3 and antidepressants
Dopamine neurodynamics
Reward deficiency syndrome
Dopamine and reward signalling
The genetics of affective disorders
Depression, dopamine and dextroamphetamine
The dopamine D3 receptor and neuropsychiatric disorders


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