The role of corticotropin releasing factor
in depressive illness: a critical review

by
Mitchell AJ Department of Liaison Psychiatry,
Addenbrooke's Hospital,
Cambridge, UK.
Neurosci Biobehav Rev 1998 Sep; 22(5):635-51


ABSTRACT

Corticotropin-releasing factor (CRF) is the principal neuropeptide involved in regulating the stress response. When centrally administered to animals it produces somatic changes analogous to those seen in both depression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically seen in depressed patients. A literature search using Medline, Embase Psychiatry, PsycLIT and BIDS from 1996-1997 revealed 25 studies that have examined CRF concentrations in patients with affective disorder. The methodology of these studies varies and they can be criticised, in particular, for failing to consider the stress response of the lumbar puncture. Recently, post-mortem immunocytochemical techniques have been employed to help clarify the nature of these abnormalities in depression. On balance, evidence from CSF sampling, post-mortem findings and dynamic endocrine studies suggests that both hypothalamic and extra-hypothalamic concentrations of CRF are moderately elevated in a proportion of currently antidepressant treatment, high CRF concentrations tend to normalise. The causes of increased CRF output in depression are also unknown but may involve an integration of remote vulnerability factors and recent stressors perhaps mediated through impaired function of glucocorticoid receptors. Ultimately, the careful manipulation of CRF may hold therapeutic promise for sufferers of mood disorders.
CRH
MTIP
LHPA
Astressin
Urocortin
21st century
Ketoconazole
Cortisol blues
Sigma ligands
CRF and memory
Drugs and reward
CRH-R antagonists
Residual depression
CRF and drug addiction
Anxiety and depression
Sedatives and anxiolytics
Glucocorticoids and mood
Stress, depression and the rat
Antidepressants and cell growth
Are antidepressants neuroprotective?
Melancholia, hypercortisolism and CRH
Stress, dynorphin, dysphoria and the kappa opioid system


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