Intraventricular infusion of the histamine H(1) receptor antagonist chlorpheniramine improves maze performance and has anxiolytic-like effects in aged hybrid Fischer 344xBrown Norway rats
by
Hasenohrl RU, Weth K, Huston JP.
Institute of Physiological Psychology
and
Center for Biological and Medical Research,
University of Dusseldorf, Germany.
hasenoeh@uni- duesseldorf.de
Exp Brain Res. 1999 Oct;128(4):435-40


ABSTRACT

In the present study we analyzed the effect of continuous intraventricular infusion of the histamine H(1) receptor antagonist d-chlorpheniramine on the performance of 32-month-old Fischer 344/Brown Norway F1 hybrid rats in the place version of the Morris water maze and in two different tests of anxiety (open field and black-and-white exploration). Control groups included vehicle-infused old and adult (3-month-old) F1 hybrids. Chronic infusion of chlorpheniramine improved the maze performance of the old rats and reduced fear-related behaviors in the open field and black-and-white box. Furthermore, long-term administration of chlorpheniramine was found to diminish age-related deficits in motor capacities. The findings substantiate that histamine H(1)-receptive sites are involved in learning and fear-related processes and indicate that hypomnesia and hyperanxiety seen in the course of brain aging may be based, in part, on hyperactivation of the central histaminergic neuron system. Furthermore, the data contribute to the behavioral characterization of the Fischer 344/Brown Norway F1 hybrid rat in the context of behavioral gerontopharmacology.
H3
Caffeine
Adrafinil
Modafinil
Mirtazapine
Noradrenaline
Methylphenidate
Sleep deprivation
Retarded depression
Diphenhydramine (Benadryl)
Types of depression and mood-disorder
Antihistamines, cognition and performance
Antihistamines: dimenhydrinate (Dramamine)
Diphenhydramine (Benadryl) and venlafaxine
Histamine H3 receptor antagonist/inverse agonists
Chlorpheniramine (Aller-Chlor, Chlo-Amine) and cocaine

Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family