Pharmacological enhancement of cannabinoid CB(1) receptor activity elicits an antidepressant-like response in the rat forced swim test
by
Hill MN, Gorzalka BB.
Department of Psychology,
University of British Columbia,
Vancouver, 2136 West Mall,
Canada V6T 1Z4.
Eur Neuropsychopharmacol. 2005 May 22


ABSTRACT

These experiments aimed to assess whether enhanced activity at the cannabinoid CB(1) receptor elicits antidepressant-like effects. To examine this we administered 1 and 5 mg/kg doses of the endocannabinoid uptake inhibitor AM404; 5 and 25 mug/kg doses of HU-210, a potent CB(1) receptor agonist; 1, 2.5 and 5 mg/kg of oleamide, which elicits cannabinoidergic actions; 1 and 5 mg/kg doses of AM 251, a selective CB(1) receptor antagonist, as well as 10 mg/kg desipramine (a positive antidepressant control) and measured the duration of immobility, during a 5-min test session of the rat Porsolt forced swim test. Results demonstrated that administration of desipramine reduced immobility duration by about 50% and that all of AM404, oleamide and HU-210 administration induced comparable decreases in immobility that were blocked by pretreatment with AM 251. Administration of the antagonist AM 251 alone had no effect on immobility at either dose. These data suggest that enhancement of CB(1) receptor signaling results in antidepressant effects in the forced swim test similar to that seen following conventional antidepressant administration.
CB1
Reward
Cannabis
Dopamine
Cannabinoids
Drug screening
The hungry hydra
The nectar of delight
The pregnant smoker
Why is cannabis fun?
Abstinence syndrome
Cannabinoid antagonists
Cannabinoids/neogenesis
Cannabis and cannabinoids
Cannabinoids, opioids and pain
Cannabis seeds and stoned mice
Cannabinoids in vitro and in vivo


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family