Bupropion exposures: clinical manifestations and medical outcome
Belson MG, Kelley TR.
Department of Pediatrics,
Emory University School of Medicine,
Atlanta, Georgia, USA
J Emerg Med 2002 Oct;23(3):223-30


Bupropion is an antidepressant and smoking cessation aid. Limited toxicological information exists for intentional and unintentional bupropion-only exposures. A retrospective review of all bupropion-only exposures reported to the Toxic Exposure Surveillance System from 1998 through 1999 was conducted. Data for the three bupropion products, Wellbutrin, Wellbutrin SR, and Zyban, included demographics, reason for exposure, clinical effects, therapy, and medical outcome. A total of 7,348 bupropion-only exposures were reported: 56% female and 61% unintentional. The majority of exposures involved Wellbutrin SR; however, Wellbutrin exposures involved a higher percentage of intentional overdoses and serious clinical effects. Clinical effects related to bupropion were noted in 2,247 (31%) exposures; 8% of all children <6-years-old compared to 46% of all teenagers. Seizures developed in 15% of all intentional exposures. Cardiovascular disturbances were extremely uncommon after overdose. The majority of unintentional bupropion-only exposures result in minimal or no clinical toxicity; however, a significant number of intentional overdoses result in seizures.
Bupropion and REM
Bupropion and mania
Bupropion and seizures
Bupropion and smoking
Bupropion for dysthymia
Bupropion and depression
Bupropion versus trazodone
Bupropion versus paroxetine
Bupropion and its metabolites
Sertraline for anxious depressives
Bupropion (Wellbutrin) : structure
Bupropion for ADHD and bipolar disorder
Bupropion versus methylphenidate (Ritalin)
Bupropion (Wellbutrin) for major depressive disorder
Bupropion: pharmacology and therapeutic applications
Bupropion (Wellbutrin): neurochemical and psychotropic effects

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