The role of dysregulated amygdalic
emotion in borderline personality disorder

Corrigan FM, Davidson A, Heard H
Argyll and Bute NHS Trust,
Argyll and Bute Hospital,
Lochgilphead, UK.
Med Hypotheses 2000 Apr; 54(4):574-9


Borderline personality disorder (BPD), is a condition that has a high mortality and is associated with much distress for the sufferers as well as with difficult management problems for health professionals. Taking emotional dysregulation as the core feature of BPD, the authors propose that the disorder arises from impaired modulation of subcortical inputs to consciousness. We hypothesize that the amygdaloid complex, and its connections with thalamus, cingulate cortex and insular cortex are critical in the development and maintenance of the disorder. If this is the case, peptides such as galanin, somatostatin and cholecystokinin will be the most important neurotransmitters, thus explaining the relative lack of efficacy of standard antipsychotic and antidepressant drugs
21st Century
Bipolar disorder
Hedonic set-point
The guilt-free soldier
Hippocampal remodelling
Subgenual prefrontal cortex
The amygdala and dysthymia
Inner workings of the amygdala
The amygdala the dopamine system
Omega-3 for borderline personality disorder

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family