Differential regulation of Brain Derived Neurotrophic Factor transcripts by antidepressant treatments in the adult rat brain
by
Dias BG, Banerjee SB, Duman RS, Vaidya VA.
Department of Biological Sciences,
Tata Institute of Fundamental Research,
Homi Bhabha Road, Colaba,
400 005, Mumbai, India
Neuropharmacology. 2003 Sep;45(4):553-63.


ABSTRACT

Antidepressants are known to increase brain derived neurotrophic factor (BDNF) mRNA in the adult rat brain. The BDNF gene has four differentially regulated promoters that generate four transcript forms, each containing a unique non-coding 5' exon (exon I-IV) and a common 3' coding exon. Using in situ hybridization with exon-specific riboprobes, we have examined whether diverse classes of antidepressants recruit a single or multiple BDNF promoters to regulate BDNF mRNAs. The antidepressants tested were electroconvulsive seizure (ECS) and the pharmacological antidepressants tranylcypromine, desipramine and fluoxetine. The effects of both acute and chronic ECS were the most prominent on exon I and II containing BDNF mRNAs in hippocampal and cortical subfields. Chronic ECS enhanced the acute induction of exon I, II and IV mRNAs but did not influence the acute upregulation of exon III mRNAs. Acute pharmacological antidepressants resulted in region-specific decreases in distinct exon-specific BDNF transcripts. In contrast, chronic administration with tranylcypromine and desipramine enhanced exon II and exon III mRNAs, respectively, in discrete hippocampal and cortical subfields. Chronic fluoxetine treatment did not have a significant effect on the exon-specific BDNF transcripts. The results indicate that distinct antidepressants differentially regulate BDNF mRNAs through a region-specific recruitment of the four BDNF promoters and suggest that diverse signaling mechanisms may be recruited to regulate BDNF transcripts.
BDNF
CREB
Statins
Options
Exercise
Sexercise
21st Century
CREB and BDNF
Antidepressants
Atypical depression
Retarded depression
BDNF and social defeat
Exercise and depression
BDNF and new brain cells
Nootropics ('smart drugs')
How do antidepressants work?
Antidepressants and new brain cells
Social isolation selectively reduces BDNF
Runners' high: exercise and endogenous opioid release
BDNF: flipping the brain's addiction switch without drugs
Brain-derived neurotrophic factor (BDNF) and mental health
AMPA receptors and brain-derived neurotrophic factor (BDNF)
Voluntary exercise produces antidepressant and anxiolytic behavioral effects
Environmental enrichment and voluntary exercise massively increase neurogenesis


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family