Apomorphine-induced penile erections
in Parkinson's disease

by
O'Sullivan JD, Hughes AJ
Neurology Department,
Austin & Repatriation Medical Centre,
West Heidelberg, Victoria, Australia.
Mov Disord 1998 May; 13(3):536-9


ABSTRACT

Penile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations. Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use. Animal studies suggest central D2-type dopamine receptor stimulation and oxytocin release from the paraventricular nucleus of the hypothalamus mediate the effect. Erections reported with other dopamine agonists and levodopa are probably mediated by the same mechanism. Apomorphine-induced erections in PD are probably more common than previously thought. The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD.


D2
SSRIs
Viagra
Oxytocin
Levodopa
Bupropion
Yohimbine
Amineptine
Testosterone
Phentolamine
DHEA and sex
Parkinsonian pain
Parkinson's disease
Apomorphine: dosage
Apomorphine: structure
Apomorphine: mechanisms
Parkinson's disease: resources
Apomorphine and sexual function
Apomorphine (Uprima) : structure
The pharmacology of penile erection
Psychotropic medications and sexual dysfunction


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