Drug mechanisms in anxiety
by
Bourin M, Hascoet M.
Address JE 2029 Neurobiologie de l'Anxiete et de la Depression,
Faculte de Medecine, Nantes, France.
mbourin@sante.univ-nantes.fr
Curr Opin Investig Drugs 2001 Feb;2(2):259-65


ABSTRACT

The most common and successful therapyfor the majority of patients suffering from anxiety is treatment with benzodiazepines (BZDs). The problem of drug-induced dependency following treatment with these drugs may be avoided by developing more selective and specific BZD compounds, such as 2,3-substituted BZDs. Alternative approaches to the treatment of anxiety include the following: (i) antidepressants such as the selective serotonin reuptake inhibitors (SSRIs), which are active in treating most anxiety disorders, including GAD; (ii) metabotropic glutamate (mGluR2) receptor agonists, which negatively modulate glutamate neurotransmission, and CRF antagonists, which have been proposed to exhibit anxiolytic properties; (iii) 5-HT1A receptor agonists which have demonstrated anxiolytic effects in clinical studies, although preclinical studies have reported weak or variable effects; (iv) 5-HT moduline antagonists, as well as 5-HT2C receptor antagonists, which may have anxiolytic properties; and, finally, (v) other approaches which are under investigation, including CCK2 antagonists.
GAD
SSRIs
Stress
Anxiety
Buspirone
Lorazepam
Barbiturates
Meprobamate
Benzodiazepines
Anxiety resources
Future anxiolytics
Anxiety and depression
Levetiracetam (Keppra)
The neural basis of anxiety
Anxiolytics/antidepressants
Neurobiology and genetics of anxiety
Anxioselective compounds and GABA(A)
Diazepam (Valium) and the potato: the natural origin of benzodiazepines


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