The chances of new atypical substances
by
Falkai P, Vogeley K
Klinik fur Psychiatrie und Psychotherapie,
Universitat Bonn.
falkai@uni-bonn.de
Fortschr Neurol Psychiatr 2000 Apr; 68 Suppl 1:S32-7


ABSTRACT

Antipsychotic treatment with so-called "atypical" neuroleptics, as defined by the lack of extrapyramidal side effects in its strict sense, has made great advances in the last decades with the advent of newly developed antipsychotic agents. The first atypical neuroleptic drug was clozapine, also referred to as "dirty drug" or "rich drug" because of its broad receptor binding profile. Clozapine has been the starting point for several different, newly developed antipsychotics. Among these, the most prominent are olanzapine, risperidone, sertindol, ziprasidone, and amisulpride. All of these newly developed, atypical antipsychotics show a high degree of efficacy in the treatment of positive symptoms of schizophrenia in combination with a lack of or a reduced degree of extrapyramidal side effects (EPS). In addition, several atypical antipsychotics seem to have an additional impact on negative symptoms such as alogia, anhedonia, or avolition. However, apart from the clear advantage of clozapine in the treatment of otherwise treatment-resistant schizophrenia, differential indications for the different antipsychotics remain to be established.
Deliriants
Quetiapine
Olanzapine
LY2140023
Amisulpride
Trimipramine
Antipsychotics
Chlorpromazine
The deficit syndrome
Antipsychotics: review
Schizoaffective disorder
Schizophrenia: new drugs
Bipolars and schizophrenics
Atypical antipsychotic agents
Are atypicals antidepressants?
Partial dopamine agonists for psychosis
Big Pharma and drugs for schizophrenics
Atypical antipsychotics for schizophrenia
5-HT2a inverse agonists as antipsychotics
Atypicals versus traditional antipsychotics


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