The use of anticonvulsants to augment
antidepressant medication

by
Dietrich DE, Emrich HM
Abteilung Klinische Psychiatrie und Psychotherapie,
Medizinische Hochschule Hannover, Germany.
J Clin Psychiatry 1998; 59 Suppl 5:51-8; discussion 59


ABSTRACT

Combination therapy that couples classical antidepressants with other psychoactive compounds is one of the major therapeutic strategies in therapy-resistant depression. The authors review reports on the antidepressive effects of the mood stabilizers carbamazepine and valproate and focus on the pharmacodynamic and clinical aspects of combining these compounds with antidepressant drugs. In addition, a pivotal study (N=10 outpatients) demonstrates the use and efficacy of a low-dose combination therapy of carbamazepine and amitriptyline. It is concluded that low-dose combination of classical antidepressants and mood stabilizers appears to be well tolerated and highly effective.
Options
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Dysthymia
Pregabalin
Anhedonia
Melancholy
Nefazodone
Mood stabilisers
Sodium valproate
Drugs and reward
PTSD and bereavement
Epilepsy and depression
Anticonvulsants and suicide
Neurobiology and genetics of anxiety
Anxioselective compounds and GABA(A)
Anticonvulsants as antidepressants for bipolars


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