Allergy and depression: a neurochemical threshold
model of the relation between the illnesses

by
Marshall PS
Department of Psychiatry,
Hennepin County Medical Center,
Minneapolis, Minnesota 55415.
Psychol Bull 1993 Jan; 113(1):23-43


ABSTRACT

Empirical studies suggest a very high prevalence of atopic disorder in people with depression. Research indicates that individuals with allergy have cholinergic hyperresponsiveness and beta-adrenergic hyporesponsiveness in the autonomic nervous system. Evidence is reviewed that similar imbalances in central nervous system cholinergic-adrenergic activity play a casual role in depression behaviors. It is hypothesized that the allergic state or allergic reactions can accentuate cholinergic-adrenergic activity imbalances in the central nervous system of a small subgroup of people at risk for endogenous depression thereby producing depression symptomatology.
Depression
Noradrenaline
New antidepresants
New drugs for eczema
Asthma and depression
Eczema and depression
The cholinergic-adrenergic axis
Allergy, depression and backpain
Tianeptine and depressive asthmatics
St John's wort (Kira, Alterra) for atopic dermatitis


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