Increased anxiety of mice
lacking the serotonin1A receptor
Parks CL, Robinson PS, Sibille E, Shenk T, Toth M.
Howard Hughes Medical Institute,
Department of Molecular Biology,
Princeton University, Princeton, NJ 08544-1014, USA.
Proc Natl Acad Sci U S A 1998 Sep 1;95(18):10734-9
ABSTRACTBrain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.5-HT2
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