The role of serotonergic system in the mechanism
of action of antidepressant agents

Wielosz M
Katedry i Zakadu Farmakologii AM w Lublinie.
Psychiatr Pol, 1996 Nov, 30:6, 963-72


Thirty eight years after the successful clinical introduction of antidepressant agents, there has been an important progress in the knowledge and changes in thinking about the role of central serotonergic system in depression and in the mechanism of their therapeutic efficacy. Although it is not clear whether an increase or decrease in serotoninergic function is more important in antidepressant action of agents, there is increasing evidence that almost all antidepressant drugs can induce changes in the sensitivity of somotodendritic 5-HT1A autoreceptors and postsynaptic 5-HT2 receptors in spite of very different pharmacological profiles after a single administration. The question arises as to the causal nature of the relationship between these effects and beneficial clinical action. Further studies are still required to dispel these doubts.
Serotonin: structure
Serotonin and aggression
SSRI-induced melancholy
Serotonin-releasing agents
Serotonin and psychedelics
SSRIs and sexual functioning
Serotonin and romantic lovers
Acute SSRIs and emotional processing
Serotonin and the genetics of depression
Off-label use of selective serotonin reuptake inhibitors (SSRIs)

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