Contributions of 5-HT(2C) receptors to multiple
actions of central serotonin systems

by
Giorgetti M, Tecott LH.
Center for Neurobiology and Psychiatry,
University of California,
San Francisco School of Medicine,
401 Parnassus Avenue,
San Francisco, CA 94143-0984, USA.
Eur J Pharmacol. 2004 Mar 19;488(1-3):1-9


ABSTRACT

Insights into neural mechanisms through which central serotonin (5-HT) systems influence brain function may be gained by examining the contributions of individual 5-HT receptor subtypes. Significant attention has focused on the 5-HT(2C) receptor subtype, which is abundantly expressed throughout the central nervous system and displays high-affinity interactions with a wide variety of psychiatric medications. Both pharmacological and genetic approaches to the analysis of 5-HT(2C) receptor function reveal that it contributes substantially to the serotonergic regulation of a wide variety of behavioral and physiological processes. For example, significant inhibitory effects of 5-HT(2C) receptor stimulation have been observed in both limbic and striatal dopamine pathways. These may contribute to the effects of experimental 5-HT(2C) receptor manipulations on responses to psychostimulant, atypical antipsychotic and antidepressant drugs. Further evidence for a role of these receptors in affect regulation arises from recent findings that alterations in 5-HT(2C) mRNA editing are observed in the brains of suicide victims with a history of depression and in animals exposed to antidepressant drug treatment. Finally, we will review a growing body of evidence indicating a role of 5-HT(2C) receptors in the serotonergic regulation of energy balance. Pharmacological and genetic studies reveal these receptors to influence feeding, glucose homeostasis and the energy efficiency of physical activity.
LSD
SSRIs
5-HT2
5-HT3
5-H2c
5-HT1a
5-HT2a
Serotonin
Dopamine
Mianserin
Amitriptiline
Agomelatine
RNA silencing
Antidepressants
Transcriptomics
Pharmacogenetics
Pharmacogenomics
Transcriptomics/5-HT2c
Serotonin 5-HT2C receptors


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