Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C.
Mount Sinai Graduate School of Biological Sciences,
New York, NY 10029, USA.
Neuron 2002 Apr 25;34(3):349-56
ABSTRACTFive adenosines within the coding sequence of the serotonin 2C receptor (5-HT2C) pre-mRNA are converted to inosines by RNA editing (named A, B, C' (E), C, and D sites). In human prefrontal cortex (PFC), the most abundant 5-HT2C mRNA sequences result from editing at the A site, or from the editing combinations AC'C, ABCD, and ABD. In suicide victims with a history of major depression, C' site editing is significantly increased, D site editing is significantly decreased, and the C site shows a trend toward increased editing. Treatment of mice with the antidepressant drug fluoxetine (Prozac) causes changes in C', C, and D site editing that are exactly opposite to those seen in suicide victims. Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims.LSD
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