The medical benefit of 5-HT research
by
Jones BJ, Blackburn TP.
Psychiatry Research Department,
GlaxoSmithKline, New Frontiers Science Park,
Third Avenue, Harlow,
CM19 5AW, Essex, UK.
b_j_jones@gsk.com
Pharmacol Biochem Behav 2002 Apr;71(4):555-681


ABSTRACT

5-HT research is now more than 50 years old, and it has generated a wealth of therapeutic agents, some of which have had a major impact on disease management. The 5-HT reuptake inhibitors (SSRIs) are among the most widely prescribed drugs for treating depression and a variety of other disorders including anxiety, social phobia and premenstrual dysphoria (PMD). The other major success stories of 5-HT research are the discovery of 5-HT1B/D receptor agonists for treating migraine and 5-HT3 receptor antagonists for chemotherapy and radiation-induced emesis. The role of 5-HT in the mechanism of action of antipsychotic agents remains a topic of intense research, which promises better treatments for schizophrenia in the future. Compounds interacting with 5-HT1F, 5-HT2C, 5-HT6 and 5-HT7 receptors are currently under investigation and may prove to have important therapeutic applications in the future.
TCAs
SSRIs
Suicide
Serotonin
Dopamine
Melancholia
Noradrenaline
SSRI spectrum
SSRI mechanisms
Future anxiolytics
MDMA neurotoxicity
21C antidepressants
The serotonin receptors
Serotonin and psychedelics
SNaRIs, NaSSAs, and NaRIs
Serotonin and romantic lovers
Neuropharmacology of serotonin
The monoamine theory of depression
Fluoxetine (Prozac): 10th Anniversary
Serotonin and the genetics of depression
Are SSRI antidepressants little better than placebos?

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