Pathological laughter following
intravenous sodium valproate
by
Jacob PC, Chand RP
Department of Medicine (Neurology),
College of Medicine,
Sultan Qaboos University, Muscat, Oman.
Can J Neurol Sci 1998 Aug; 25(3):252-3

ABSTRACT

BACKGROUND: Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease. METHOD: Case Studies. RESULT: Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy. CONCLUSION: Pathological laughter can be a side effect of intravenous sodium valproate.

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