Does selegiline modify the progression of early Parkinson's disease? Results from a five-year study
by
Larsen JP, Boas J, Erdal JE
Department of Neurology,
Central Hospital of Rogaland, Stavanger, Norway
and
Department of Neurology,
University Hospital of Bergen,
Bergen, Norway.
Eur J Neurol 1999 Sep; 6(5):539-547

ABSTRACT

The objective of this study was to examine the effect of long-term treatment with selegiline on the progression of Parkinson's disease (PD). One hundred and sixty-three patients with early PD were treated with levodopa and benserazide, combined with selegiline or placebo in a five-year randomized, placebo-controlled, double-blind, parallel group study followed by a one-month wash-out of selegiline or placebo. The main outcome measures were assessments of the severity of parkinsonism, levodopa requirements and the development of end-of-dose motor fluctuations over time and after wash-out at the end of the study period. Results indicated that patients treated with the combination of selegiline and levodopa developed markedly less severe parkinsonism and required lower doses of levodopa during the five-year study period than patients treated with levodopa and placebo. There was no trend towards worsening during wash-out among patients previously treated with selegiline. The results cannot easily be explained by a symptomatic effect of selegiline.

MAOIs
Levodopa
Selegiline
Dopamine
Cabergoline
Selegiline reviewed
Parkinson's disease: resources
Selegiline: product information
Tramadol and Parkinson's disease
Selegiline and Alzheimer's disease
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Hedonistic homeostatic dysregulation
EMSAM (transdermal selegiline patch)

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