Antidepressant activity of
S-adenosyl-L-methionine in mice and rats
Czyrak A, Rogoz Z, Skuza G, Zajaczkowski W, Maj J
Institute of Pharmacology,
Polish Academy of Sciences, Krakow.
J Basic Clin Physiol Pharmacol 1992 Jan-Mar; 3
S-Adenosyl-L-methionine (SAM), main methyl donor, was tested in mice and rats
in several models which are predictive of possible antidepressant activity. In
the forced swimming test in rats the effect of SAM was compared with that of the
tricyclic antidepressant amitriptyline. SAM decreased dose-dependently
immobility time in the forced swimming test in mice and rats, these effects
being antagonized by haloperidol and prazosin (the latter only in rats).
Locomotor or exploratory activity in mice and rats was not increased by SAM.
D-Amphetamine-induced locomotor hyper-activity in rats was increased by repeated
(14 days, twice daily) treatment with SAM. Behavioural stimulation induced by
D-amphetamine or L-dopa (given with benserazide) in mice was not changed by a
single dose of SAM. The drug reduced hypothermia induced by apomorphine in mice.
Hypothermia induced by reserpine or clonidine in mice was not antagonized. SAM
increased the amplitude of the acoustic startle reflex. The above results
indicate that the psychopharmacological profile of SAM resembles that of
antidepressants in only some tests. The mechanism by which SAM produces its
antidepressant effect needs further investigation.
Kava versus valerian
Substance P inhibitors
SAMe as an antidepressant
Nitric oxide synthase inhibitors
SAMe (SAMe): bioavailability and safety
Methionine, S-adenosyl-l-methionine (SAMe) and the brain
SAMe (S-adenosyl-L-methionine) versus imipramine (Tofranil)