Psychomotor retardation
and anhedonia in depression
by
Lemke MR, Puhl P, Koethe N, Winkler T
Department of Psychiatry,
University of Kiel, Germany.
Acta Psychiatr Scand 1999 Apr; 99(4):252-6
ABSTRACT
Anhedonia, the inability to experience pleasure, and observed changes in
psychomotor performance are frequent psychopathological phenomena in major
depression with possible common neurobiological mechanisms. Interest, pleasure
and reactivity to pleasurable stimuli contribute to movement generation and
observable behaviour. Therefore the relationship between anhedonia and
psychomotor retardation was studied in 48 depressed patients. Subjectively
experienced anhedonia correlated with self-rated but not with observer-rated
global severity of depression. There was a significant correlation between
anhedonia and psychomotor retardation assessed with the Widocher Retardation
Scale. The results suggest the existence of an empirical relationship between
reduced ability to experience pleasure and observable psychomotor retardation in
depression. Specific measures of psychomotor phenomena may provide further
insights into the relationship between observable behaviour and self-experienced
symptoms in depression.
Options
Dopamine
Bupropion
Anhedonia
Amineptine
Nomifensine
Hypersomnia
Noradrenaline
Antidepressants
Methylphenidate
Tranylcypromine
Chronic depression
Atypical depression
Depressive realism
An individualised approach
Parkinsonian signs in depressives
Types of depression and mood-disorder
The catecholamine hypothesis of depression
Depression, dopamine and dextroamphetamine
Mesolimbic medium spiny neurons and pleasure
Regulation of synapses in the nucleus accumbens
The nucleus accumbens: opioids versus cannabinoids