Phosphodiesterase 5 inhibitors
in male sexual dysfunction

by
Kuthe A.
Curr Opin Urol. 2003 Sep;13(5):405-10


ABSTRACT

PURPOSE OF REVIEW Phosphodiesterase 5 inhibitors are preferred by most men for the oral treatment of erectile dysfunction. In many guidelines, this therapy is recommended as first-line therapy because of convenience, high efficacy, and low rates of side-effects. Sildenafil was the first drug for the treatment of erectile dysfunction, introduced in 1998. There are now two new phosphodiesterase 5 inhibitors, vardenafil and tadalafil, for which approval was recently given in the European Union and is expected this year in the United States.RECENT FINDINGS Sildenafil has proved to be a very effective medicinal product. According to initial studies, vardenafil and tadalafil have demonstrated efficacy comparable to that of sildenafil. However, fewer data are available evaluating the adverse effects of vardenafil and tadalafil, particularly on their long-term use and their use in high-risk groups. Interestingly, vardenafil and tadalafil have a higher potency than sildenafil. Moreover, the long life of tadalafil has been associated with an erectogenic potential of the drug lasting for more than 24 h. The advantage of this is the possibility of a patient engaging in sexual activity more than once after a single administration of the drug.SUMMARY In the future, in addition to sildenafil, the new phosphodiesterase 5 inhibitors vardenafil and tadalafil will play an important role in the management of erectile dysfunction, depending on the patient's health profile.


Tadalafil
Vardenafil
Delequamine
Apomorphine
Testosterone
Phentolamine
Coolidge effect
Sexual pharmacology
Vardenafil and the heart
Tianeptine for better sex
Drugs for impotent rabbits
Semen as an antidepressant?
Vardenafil and penile tumescence
Yohimbine and sexual performance
The pharmacology of penile erection
Vardenafil (Levitra, Nuviva) for diabetics
Viagra v Levitra as recreational sex-drugs


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family