Other symptoms of advanced stage Parkinson's disease
by
Pollak P, Tranchant C
Service de Neurologie,
CHU de Grenoble,
38043 Grenoble Cedex 9 et Inserm U 318,
Universite Joseph Fourier de Grenoble.
Rev Neurol (Paris) 2000 Jun;156 Suppl 2Bis:165-173


ABSTRACT

Autonomic dysfunction, neuropsychiatric problems, axial signs and sleep disorders are common complications of advanced Parkinson's disease (PD). Urinary disturbance due to detrusor hyperreflexia and iatrogenic orthostatic hypotension are prominent dysautonomic signs. Depression and anxiety are frequent but can occur exclusively during off periods. A fronto-sub cortical dementia occurs in 30% of PD patients, but anti-parkinsoniens drugs (APD) can cause hallucinations even in non demented PD patients. Axial signs, such as freezing, postural instabily or dysarthria become doparesistant. Insomnia, REM sleep disorders. At least, pain is very frequent. Exact analysis of these signs is important for an adequate treatement: most of them are improved by APD but some of them, like orthostatic hypotension or hallucinations, are increased by these drugs.
Isatin
Selegiline
Levodopa
Dopamine
Tolcapone
Rasagiline
Cabergoline
Bromocriptine
Dopaminergics
Parkinsonian pain
Pramipexole : review
Parkinson's disease: resources
Caffeine and Parkinson's disease
Tramadol and Parkinson's disease
Mianserin and Parkinson's disease
Selegiline and Parkinson's disease
Apomorphine and Parkinson's disease
Hedonistic homeostatic dysregulation
Parkinsonian signs/symptoms in depressives
L-dopa in the treatment of Parkinson's disease


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