Substance P and the neurokinins: novel peptide
neurotransmitters in psychopharmacology

by
Stahl SM
Clinical Neuroscience Research Center
San Diego
and the Department of Psychiatry
University of California San Diego, USA.
J Clin Psychiatry 1999 Feb; 60(2):77-8


ABSTRACT

A new neurotransmitter system is a family of 3 related peptides known as neurokinins. The best known of these is substance P. The others are known simply as neurokinin A and neurokinin B. The specific receptor subtypes that correspond to these 3 neurokinins are neurokinin 1 receptors for substance P, neurokinin 2 receptors for neurokinin A, and neurokinin 3 receptors for neurokinin B. These neurotransmitters appear to play a key role in the regulation of emotions, and antagonists of their receptors may be novel psychotropic drugs of the future.

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