Acute effects of mirtazapine on sleep continuity and sleep architecture in depressed patients: a pilot study
by
Winokur A, Sateia MJ, Hayes JB,
Bayles-Dazet W, MacDonald MM, Gary KA
Department of Psychiatry,
Dartmouth Medical School,
Hanover,
New Hampshire, USA
Biol Psychiatry 2000 Jul 1; 48(1):75-78


ABSTRACT

Background: Mirtazapine, a clinically effective antidepressant, acts by antagonizing central alpha(2)-adrenergic and 5-HT(2)/5-HT(3) receptors. No data are available regarding mirtazapine's effects on sleep architecture in patients with major depressive disorder.Methods: Six patients meeting criteria for major depressive disorder and scoring >/=4 on the three Hamilton Depression Rating Scale sleep items were studied. Polysomnographic evaluations were performed at baseline and after 1 (15 mg at bedtime) and 2 weeks (30 mg at bedtime) of open-label mirtazapine treatment.Results: Mirtazapine significantly decreased sleep latency and significantly increased total sleep time and sleep efficiency from baseline levels during week 1, with similar results observed after week 2. Mirtazapine did not significantly alter rapid eye movement sleep parameters. Clinically, Hamilton Depression Rating Scale and sleep disturbance ratings improved after treatment.Conclusions: Mirtazapine significantly improves sleep continuity in major depressive disorder patients with poor sleep quality at weeks 1 and 2 of treatment, while preserving sleep architecture.
TCAs
SSRIs
Options
Anhedonia
Imipramine
Melancholy
Mirtazapine
Mirtazapine v SSRIs
Mirtazapine: overview
Mirtazapine: structure
Mirtazapine v sertraline
Paroxetine v mirtazapine
Imipramine and depression
Mirtazapine and depression
Antidepressant mechanisms
Mirtazapine and the receptors
Mirtazapine: pharmacokinetics
Mirtazapine/negative symptoms