Melancholia with onset
during treatment with SSRIs

by
Swartz CM, Guadagno G
Department of Psychiatry,
East Tennessee State University,
Johnson City, USA.
Ann Clin Psychiatry 1998 Dec; 10(4):177-9


ABSTRACT

A defined group of medical records was surveyed for patients who showed onset of major depression with melancholic features while taking an antidepressant medication. Nine cases resulted. In all the antidepressants being taken while melancholia began were SSRIs and the melancholic depression remitted rapidly with the first treatment given, bupropion in five males, nortriptyline with triiodothyronine in two females, and ECT in one male and one female. This suggests that patients who take SSRIs and are melancholic respond well to bupropion, nortriptyline, or ECT. These observations complement reports of low responsivity of melancholic depression to SSRIs and distinctions between melancholic and nonmelancholic depressions.
SSRIs
Apathy
Selegiline
Bupropion
Reboxetine
Amineptine
Antidepressants
Methylphenidate
SSRI suicide link?
SSRIs and emotion
SSRIs v venlafaxine
Fluoxetine and reward
Serotonin reuptake inhibition
Dopamine reuptake inhibition
SSRIs and emotional blunting
Noradrenaline reuptake inhibition
SSRIs and cognitive performance
SSRIs compared with tricyclic antidepressants
Are SSRI antidepressants little better than placebos?


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