Amisulpride versus amineptine and
placebo for the treatment of dysthymia
by
Boyer P, Lecrubier Y, Stalla-Bourdillon A, Fleurot O
Unite INSERM 302,
Hopital Salpetriere, Paris, France.
Neuropsychobiology 1999; 39(1):25-32

ABSTRACT

Amisulpride, a selective antagonist for D2 and D3 dopamine receptors, acts preferentially on presynaptic receptors increasing dopaminergic transmission at low doses. In a multicentre, 3-month, placebo-controlled study, amisulpride (50 mg/day) was compared to amineptine (200 mg/day) in the treatment of primary dysthymia. A total of 323 patients were enrolled. Amisulpride and amineptine were found to be statistically superior to placebo (p < 0.0001) on the Clinical Global Impression (item 2): 63, 64 and 33% responders, respectively; improvement of Montgomery-Asberg Depression Rating Scale and Scale for the Assessment of Negative Symptoms scores following amisulpride or amineptine treatment was twice as high as with placebo (p < 0.0001). The adverse event profile of amisulpride was similar to that of placebo except for endocrine symptoms in female patients; amineptine showed mainly events linked to psychic activation (insomnia, nervousness). Results show that amisulpride can improve symptoms of chronic depression in dysthymia.

Sulpiride
Insomnia
Chromium
Dysthymia
Anhedonia
Amineptine
Desipramine
Rank theory
Retarded depression
Mesolimbic dopamine
Hardwired happiness?
Venlafaxine for dysthymia
Amisuplride for depression
Bad moods and sick hearts
Amisulpride: pharmacokinetics
Amisulpride for negative symptoms
Dysthymia, hyperthymia, cyclothymia
Amisulpride and the dopamine D2 and D3 receptors

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