Duloxetine Eli Lilly
Anttila S, Leinonen E.
Department of Psychogeriatrics,
Tampere University Hospital, Pitkaniemi, Finland.
Curr Opin Investig Drugs 2002 Aug;3(8):1217-21
ABSTRACTDuloxetine is a serotonin (5-HT) and norepinephrine (NE) uptake inhibitor in pre-registration for depression. In vivo studies demonstrate that duloxetine inhibits 5-HT and NE transporters and this may induce an antidepressant effect . In humans, duloxetine has a low affinity for most 5-HT subtypes and for muscarinic, histamine H1, alpha1-adrenergic, alpha2-adrenergic and dopamine D2 receptors . Thus, it is not surprising that the meta-analysis of four recent clinical studies suggests duloxetine is a potent and well-tolerated antidepressant . By December 2001, Lilly had filed an NDA for depression. The launch of duloxetine is planned for the second half of 2002 , . In April 2002, filing for stress urinary incontinence was anticipated for later in 2002 . Analysts at Banc of America predicted in April 2002, that the drug will be launched in the first quarter of 2003. The company projects US $400 million in revenue in 2003 and anticipates duloxetine to reach peak sales of over US $1 billion . Analysts at Morgan Stanley, projected US $25 million in sales in the fourth quarter 2002, rising to US $900 million in 2006 . At the same time, Credit Suisse First Boston anticipated launch for late 2002, with US $220 million in duloxetine revenues in 2003 and US $457 million in 2004 .Duloxetine (Cymbalta)
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