Dopaminergic agents and stimulants
as antidepressant augmentation
strategies
by
Nierenberg AA, Dougherty D, Rosenbaum JF
Department of Psychiatry,
Massachusetts General Hospital,
Harvard Medical
School, Boston 02114, USA.
J Clin Psychiatry 1998; 59 Suppl 5:60-3; discussion 64
ABSTRACT
Dopaminergic agents and stimulants have been used to manage depression when
conventional antidepressant treatments fail. We reviewed evidence for the role
of dopaminergic dysfunction in depression, the use of dopaminergic agents as
antidepressants, and the use of dopaminergic agents and stimulants as
antidepressant adjuncts. Dopamine may be part of the pathophysiology of
depression for a subset of patients. When used with caution and an appreciation
of the potential risk of abuse, dopaminergic agents and stimulants may be useful
for patients refractory to antidepressants alone.
RDS
Cocaine
Pergolide
Selegiline
Roxindole
Dopamine
GBR12909
Amineptine
Zonisamide
Pramipexole
Nomifensine
Bromocriptine
Thyroid hormones
Dopamine and sex
Parkinson's disease
Methylphenidate SR
Serotonin-dopamine interaction
Depression, dopamine and dextroamphetamine
Mesolimbic medium spiny neurons and pleasure
Dopaminergic and noradrenergic antidepressants
Regulation of synapses in the nucleus accumbens
The nucleus accumbens: opioids versus cannabinoids
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