Neuropsychic effects of
dehydroepiandrosterone
by
Rigaud AS, Pellerin J.
Service de Medecine Interne et de Gerontologie,
Hopital Broca, CHU Cochin Port-Royal,
Universite Rene-Descartes - Paris-V,
54-56, rue Pascal, 75013 Paris.
Ann Med Interne (Paris) 2001 Apr; 152(S3):43-49

ABSTRACT

Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) are secreted primarily by the adrenal glands. DHEA could also be a neuroactive steroidal hormone. Because basal levels of DHEA and DHEA-S in humans decrease significantly with age, these hormones have been assumed to be involved in the aging process and in a number of pathologies which develop with aging: immunosenescence, increased mortality, increased incidence of cancer, osteoporosis and cardiovascular diseases. However, its role is still unknown. In humans, cross sectional and longitudinal studies have shown that DHEA might be associated with global measures of well-being and functioning, but positive effects on measures of memory and attention could not be found. Studies investigating DHEA and DHEA-S levels in dementia have produced controversial results. Short-term experimental studies have not shown significant improvement in global measures of well-being and functioning in healthy subjects but have reavealed preliminary evidence for mood enhancing and antidepressant effects of DHEA. There is no evidence that DHEA could induce addiction in human beings.

DHEA
SAMe
Inositol
Hypericum
Pregnenolone
DHEA: review
DHEA and sex
Neurosteroids
Buprenorphine
New strategies
DHEA: structure
DHEA replacement
Substance P inhibitors
DHEA as an antidepressant
DHEA and anabolic steroids
Nitric oxide synthase inhibitors

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