Dehydroepiandrosterone (DHEA)
treatment of depression
by
Wolkowitz OM; Reus VI; Roberts E; Manfredi F;
Chan T; Raum WJ; Ormiston S; Johnson R;
Canick J; Brizendine L; Weingartner H
Department of Psychiatry,
University of California,
San Francisco, School of Medicine 94143-0984, USA
Biol Psychiatry, 1997 Feb, 41:3, 311-8

ABSTRACT

Dehydroepiandrosterone (DHEA) and its sulfate, DHEA-S, are plentiful adrenal steroid hormones that decrease with aging and may have significant neuropsychiatric effects. In this study, six middle-aged and elderly patients with major depression and low basal plasma DHEA f1p4or DHEA-S levels were openly administered DHEA (30-90 mg/d x 4 weeks) in doses sufficient to achieve circulating plasma levels observed in younger healthy individuals. Depression ratings, as well as aspects of memory performance significantly improved. One treatment-resistant patient received extended treatment with DHEA for 6 months: her depression ratings improved 48-72% and her semantic memory performance improved 63%. These measures returned to baseline after treatment ended. In both studies, improvements in depression ratings and memory performance were directly related to increases in plasma levels of DHEA and DHEA-S and to increases in their ratios with plasma cortisol levels. These preliminary data suggest DHEA may have antidepressant and promemory effects and should encourage double-blind trials in depressed patients.

DHEA
SAMe
Inositol
Hypericum
Pregnenolone
DHEA: review
DHEA and sex
Neurosteroids
Buprenorphine
New strategies
DHEA: structure
DHEA replacement
Substance P inhibitors
Nootropics ('smart drugs')
DHEA as an antidepressant
DHEA and anabolic steroids
Chronic lithium use and DHEA
Nitric oxide synthase inhibitors
DHEA: pharmacology and therapeutic effects

Refs
HOME
HedWeb
Future Opioids
BLTC Research
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family