Behavioral effects of central administration of the novel CRF antagonist astressin in rats
by
Spina MG, Basso AM, Zorrilla EP, Heyser CJ,
Rivier J, Vale W, Merlo-Pich E, Koob GF
Institute for Medical Neurobiology,
Otto-von-Guericke University,
Magdeburg, Germany.
Neuropsychopharmacology 2000 Mar; 22(3):230-9


ABSTRACT

Astressin, a novel corticotropin releasing factor (CRF) antagonist, has been found to be particularly potent at inhibiting the hypothalamo-pituitary-adrenal axis. The aim of the present study was to determine the effects in rats of astressin in attenuating the anxiogenic-like response produced by social stress and intracerebroventricular (ICV) CRF administration on the elevated plus-maze, and ICV CRF-induced locomotor activation in the rat. Astressin significantly reversed the anxiogenic-like response induced by both social stress and ICV rat/humanCRF (r/hCRF) on the elevated plus-maze, but failed to block the effects of r/hCRF-induced locomotor activity in a familiar environment. When these results were compared to previous studies performed with the same paradigms using other CRF antagonists, astressin showed effects similar to those of D-PheCRF(12-41) on plus-maze performance. However, contrary to alpha-helicalCRF(9-41) and D-PheCRF(12-41), astressin had no effect on CRF-induced locomotor activity. These results suggest that astressin may have a unique anti-CRF profile compared to previously tested antagonists.
CRH
LHPA
Stress
Urocortin
Antalarmin
21st Century
Ketoconazole
Cortisol blues
Drugs and reward
Animal depression
CRH-R antagonists
Stressed tree shrews
Sedatives and anxiolytics
Glucocorticoids and mood
Neuroendocrinology of stress
Hormones, the brain and stress
CRH, CRHR1 antagonists and depression
Stress and CRH, corticosteroids and monoamines
Stress, dynorphin, dysphoria and the kappa opioid system


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family