Serotonin and Psychedelics
by
Aghajanian GK, Marek GJ
Department of Psychiatry,
Yale University School of Medicine,
New Haven, Connecticut, USA.
Neuropsychopharmacology 1999 Aug; 21(2 Suppl):16S-23S

ABSTRACT

This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic drugs from the early 1950s to the present day. There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as partial agonists at 5-HT2A and other 5-HT2 receptors in the central nervous system. The noradrenergic locus coeruleus and the cerebral cortex are among the regions where hallucinogens have prominent effects through their actions upon a 5-HT2A receptors. Recently, we have observed a novel effect of hallucinogens--a 5-HT2A receptor-mediated enhancement of nonsynchronous, late components of glutamatergic excitatory postsynaptic potentials at apical dendrites of layer V cortical pyramidal cells. We propose that an effect of hallucinogens upon glutamatergic transmission in the cerebral cortex may be responsible for the higher-level cognitive, perceptual, and affective distortions produced by these drugs.

DMT
5-HT2
5-HT2A
Lisuride
Ibogaine
Serotonin
Mescaline
Psychedelics
Noradrenaline
SSRIs: review
LSD and serotonin
New antidepressants
MAOIs and hallucinogens
LSD and cosmic consciousness
Neuropharmacology of serotonin

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