The medical benefit of 5-HT research
Jones BJ, Blackburn TP.
Psychiatry Research Department,
GlaxoSmithKline, New Frontiers Science Park,
Third Avenue, Harlow,
CM19 5AW, Essex, UK.
Pharmacol Biochem Behav 2002 Apr;71(4):555-681
5-HT research is now more than 50 years old, and it has generated a wealth of therapeutic agents, some of which have had a major impact on disease management. The 5-HT reuptake inhibitors (SSRIs) are among the most widely prescribed drugs for treating depression and a variety of other disorders including anxiety, social phobia and premenstrual dysphoria (PMD). The other major success stories of 5-HT research are the discovery of 5-HT1B/D receptor agonists for treating migraine and 5-HT3 receptor antagonists for chemotherapy and radiation-induced emesis. The role of 5-HT in the mechanism of action of antipsychotic agents remains a topic of intense research, which promises better treatments for schizophrenia in the future. Compounds interacting with 5-HT1F, 5-HT2C, 5-HT6 and 5-HT7 receptors are currently under investigation and may prove to have important therapeutic applications in the future. TCAs
The serotonin receptors
Serotonin and psychedelics
NaSSAs, and NaRIs
Serotonin and romantic lovers
Neuropharmacology of serotonin
The monoamine theory of depression
(Prozac): 10th Anniversary
Serotonin and the genetics of depression
Are SSRI antidepressants little better than placebos?